Eirik Malinen

  • Professor, Head of Department,PI; PhD
  • +47 90 68 19 51
 

Publications 2024

Hanson I, Juvkam IS, Zlygosteva O, Søland TM, Galtung HK, Malinen E, Edin NFJ (2024)
TGF-β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model
Int J Radiat Biol, 1-10 (in press)
DOI 10.1080/09553002.2024.2324476, PubMed 38442208

Huynh TM, Falk RS, Hellebust TP, Dale E, Astrup GL, Hjermstad MJ, Malinen E, Bjordal K, Kiserud CE, Herlofson BB, Nome R, Amdal CD (2024)
Chronic fatigue in long-term survivors of head and neck cancer treated with radiotherapy
Radiother Oncol, 195, 110231 (in press)
DOI 10.1016/j.radonc.2024.110231, PubMed 38518958

Publications 2023

Acosta Roa AM, Skingen VE, Rekstad BL, Undseth C, Rusten E, Hernes E, Guren MG, Malinen E (2023)
Stability of metabolic tumor volume may enable radiotherapy dose painting in anal cancer
Phys Med, 114, 103151
DOI 10.1016/j.ejmp.2023.103151, PubMed 37813051

Arous D, Lie JL, Håland BV, Børsting M, Edin NFJ, Malinen E (2023)
2D mapping of radiation dose and clonogenic survival for accurate assessment ofin vitroX-ray GRID irradiation effects
Phys Med Biol, 68 (2)
DOI 10.1088/1361-6560/acaf20, PubMed 36580679

Arous D, Schrunner S, Hansson I, Edin NFJ, Malinen E (2023)
Principal component-based image segmentation: a new approach to outline in vitro cell colonies
Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 11 (1), 18-30
DOI 10.1080/21681163.2022.2035822, PublikaID 404

Gadre SS, Singh B, Tripathi A, Malinen E, Pandey A (2023)
An investigation of luminescence properties of CaF2: Dy nanophosphor irradiated with gamma rays and low energy proton beams
Appl Radiat Isot, 197, 110821
DOI 10.1016/j.apradiso.2023.110821, PubMed 37146467

Groendahl AR, Huynh BN, Tomic O, Søvik Å, Dale E, Malinen E, Skogmo HK, Futsaether CM (2023)
Automatic gross tumor segmentation of canine head and neck cancer using deep learning and cross-species transfer learning
Front Vet Sci, 10, 1143986
DOI 10.3389/fvets.2023.1143986, PubMed 37026102

Hanekamp BA, Viktil E, Slørdahl KS, Dormagen JB, Kløw NE, Malinen E, Brunborg C, Guren MG, Schulz A (2023)
Magnetic resonance imaging of anal cancer: tumor characteristics and early prediction of treatment outcome
Strahlenther Onkol, 200 (1), 19-27
DOI 10.1007/s00066-023-02114-5, PubMed 37429949

Henjum H, Dahle TJ, Mairani A, Pilskog S, Stokkevåg C, Boer CG, Redalen KR, Minn H, Malinen E, Ytre-Hauge KS (2023)
Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET
J Appl Clin Med Phys, 24 (9), e14014
DOI 10.1002/acm2.14014, PubMed 37161820

Huynh BN, Groendahl AR, Tomic O, Liland KH, Knudtsen IS, Hoebers F, van Elmpt W, Malinen E, Dale E, Futsaether CM (2023)
Head and neck cancer treatment outcome prediction: a comparison between machine learning with conventional radiomics features and deep learning radiomics
Front Med (Lausanne), 10, 1217037
DOI 10.3389/fmed.2023.1217037, PubMed 37711738

Huynh TM, Dale E, Falk RS, Hellebust TP, Astrup GL, Malinen E, Edin NFJ, Bjordal K, Herlofson BB, Kiserud CE, Helland Å, Amdal CD (2023)
Radiation-induced long-term dysphagia in survivors of head and neck cancer and association with dose-volume parameters
Radiother Oncol, 190, 110044
DOI 10.1016/j.radonc.2023.110044, PubMed 38061420

Juvkam IS, Zlygosteva O, Arous D, Galtung HK, Malinen E, Søland TM, Edin NJ (2023)
A preclinical model to investigate normal tissue damage following fractionated radiotherapy to the head and neck
J Radiat Res, 64 (1), 44-52
DOI 10.1093/jrr/rrac066, PubMed 36253091

Juvkam IS, Zlygosteva O, Sitarz M, Thiede B, Sørensen BS, Malinen E, Edin NJ, Søland TM, Galtung HK (2023)
Proton Compared to X-Irradiation Induces Different Protein Profiles in Oral Cancer Cells and Their Derived Extracellular Vesicles
Int J Mol Sci, 24 (23)
DOI 10.3390/ijms242316983, PubMed 38069306

Nattudurai R, Arous D, Edin NFJ, Pandey A, Malinen E (2023)
The energy dependence of BaSO4: Eu nanophosphors for thermoluminescence dosimetry of orthovoltage X-rays and low energy protons
Radiation Physics and Chemistry, 208, 110928
DOI 10.1016/j.radphyschem.2023.110928, PublikaID 438

Nattudurai R, Arous D, Edin NFJ, Pandey A, Malinen E (2023)
New characterization and evaluation of BaSO4: Eu as a thermoluminescent radiation dosimeter
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 541, 19-25
DOI 10.1016/j.nimb.2023.05.025, PublikaID 439

Niyoteka S, Seban RD, Rouhi R, Scarsbrook A, Genestie C, Classe M, Carré A, Sun R, La Greca Saint-Esteven A, Chargari C, McKenna J, McDermott G, Malinen E, Tanadini-Lang S, Guckenberger M, Guren MG, Lemanski C, Deutsch E, Robert C (2023)
A common [18F]-FDG PET radiomic signature to predict survival in patients with HPV-induced cancers
Eur J Nucl Med Mol Imaging, 50 (13), 4010-4023
DOI 10.1007/s00259-023-06320-2, PubMed 37632562

Zlygosteva O, Juvkam IS, Arous D, Sitarz M, Sørensen BS, Ankjærgaard C, Andersen CE, Galtung HK, Søland TM, Edin NJ, Malinen E (2023)
Acute normal tissue responses in a murine model following fractionated irradiation of the head and neck with protons or X-rays
Acta Oncol, 62 (11), 1574-1580
DOI 10.1080/0284186X.2023.2254481, PubMed 37703217

Zlygosteva O, Juvkam IS, Aass HCD, Galtung HK, Søland TM, Malinen E, Edin NFJ (2023)
Cytokine Levels in Saliva Are Associated with Salivary Gland Fibrosis and Hyposalivation in Mice after Fractionated Radiotherapy of the Head and Neck
Int J Mol Sci, 24 (20)
DOI 10.3390/ijms242015218, PubMed 37894899

Publications 2022

Evensen ME, Furre T, Malinen E, Løndalen AM, Dale E (2022)
Mucosa-sparing dose painting of head and neck cancer
Acta Oncol, 61 (2), 141-145
DOI 10.1080/0284186X.2021.2022200, PubMed 34991431

Hanson I, Pitman KE, Altanerova U, Altaner Č, Malinen E, Edin NFJ (2022)
Low-Dose-Rate Radiation-Induced Secretion of TGF-β3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding
Int J Mol Sci, 23 (15)
DOI 10.3390/ijms23158147, PubMed 35897723

Huynh TTM, Aass HCD, Falk RS, Astrup GL, Helland Å, Bjøro T, Bjordal K, Dale E, Hellebust TP, Herlofson BB, Malinen E, Kiserud CE, Osnes T, Amdal CD (2022)
Associations between patient-reported late effects and systemic cytokines in long-term survivors of head and neck cancer treated with radiotherapy
J Cancer Surviv, 17 (4), 1082-1093
DOI 10.1007/s11764-022-01273-1, PubMed 36350483

Langen Stokmo H, Aly M, Bowitz Lothe IM, Borja AJ, Mehdizadeh Seraj S, Ghorpade R, Miao X, Hjortland GO, Malinen E, Sorbye H, Werner TJ, Alavi A, Revheim ME (2022)
Volumetric parameters from [18 F]FDG PET/CT predicts survival in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms
J Neuroendocrinol, 34 (7), e13170
DOI 10.1111/jne.13170, PubMed 35729738

Papoutsis I, Skjei Knudtsen I, Peter Skaug Sande E, Louni Rekstad B, Öllers M, van Elmpt W, Røthe Arnesen M, Malinen E (2022)
Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom
Phys Imaging Radiat Oncol, 21, 101-107
DOI 10.1016/j.phro.2022.02.013, PubMed 35243040

Reaz F, Sjobak KN, Malinen E, Edin NFJ, Adli E (2022)
Sharp dose profiles for high precision proton therapy using strongly focused proton beams
Sci Rep, 12 (1), 18919
DOI 10.1038/s41598-022-22677-0, PubMed 36344543

Skipar K, Hompland T, Lund KV, Løndalen A, Malinen E, Kristensen GB, Lindemann K, Nakken ES, Bruheim K, Lyng H (2022)
Risk of recurrence after chemoradiotherapy identified by multimodal MRI and 18F-FDG-PET/CT in locally advanced cervical cancer
Radiother Oncol, 176, 17-24
DOI 10.1016/j.radonc.2022.09.002, PubMed 36113778

Theophanous S, Lønne PI, Choudhury A, Berbee M, Dekker A, Dennis K, Dewdney A, Gambacorta MA, Gilbert A, Guren MG, Holloway L, Jadon R, Kochhar R, Mohamed AA, Muirhead R, Parés O, Raszewski L, Roy R, Scarsbrook A, Sebag-Montefiore D, Spezi E, Spindler KG, van Triest B, Vassiliou V, Malinen E et al. (2022)
Development and validation of prognostic models for anal cancer outcomes using distributed learning: protocol for the international multi-centre atomCAT2 study
Diagn Progn Res, 6 (1), 14
DOI 10.1186/s41512-022-00128-8, PubMed 35922837

Publications 2021

Asperud J, Arous D, Edin NFJ, Malinen E (2021)
Spatially fractionated radiotherapy: tumor response modelling including immunomodulation
Phys Med Biol, 66 (17)
DOI 10.1088/1361-6560/ac176b, PubMed 34298527

Choudhury A, Theophanous S, Lønne PI, Samuel R, Guren MG, Berbee M, Brown P, Lilley J, van Soest J, Dekker A, Gilbert A, Malinen E, Wee L, Appelt AL (2021)
Predicting outcomes in anal cancer patients using multi-centre data and distributed learning - A proof-of-concept study
Radiother Oncol, 159, 183-189
DOI 10.1016/j.radonc.2021.03.013, PubMed 33753156

Gorgen A, Guttormsen M, Larsen AC, Siem S, Adli E, Edin NFJ, Gjersdal H, Henriksen G, Malinen E, Modamio V, Schoultz B, Sobas PA, Theodossiou TA, Wikne JC (2021)
The Oslo Cyclotron Laboratory
Eur. Phys. J. Plus, 136 (2), 181
DOI 10.1140/epjp/s13360-021-01150-3

Grigalavicius M, Mastrangelopoulou M, Berg K, Arous D, Ménard M, Raabe-Henriksen T, Brondz E, Siem S, Görgen A, Edin NFJ, Malinen E, Theodossiou TA (2021)
Publisher Correction: Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 12 (1), 7073
DOI 10.1038/s41467-021-27175-x, PubMed 34848706

Groendahl AR, Moe YM, Kaushal CK, Huynh BN, Rusten E, Tomic O, Hernes E, Hanekamp B, Undseth C, Guren MG, Malinen E, Futsaether CM (2021)
Deep learning-based automatic delineation of anal cancer gross tumour volume: a multimodality comparison of CT, PET and MRI
Acta Oncol, 61 (1), 89-96
DOI 10.1080/0284186X.2021.1994645, PubMed 34783610

Groendahl AR, Skjei Knudtsen I, Huynh BN, Mulstad M, Moe YM, Knuth F, Tomic O, Indahl UG, Torheim T, Dale E, Malinen E, Futsaether CM (2021)
A comparison of methods for fully automatic segmentation of tumors and involved nodes in PET/CT of head and neck cancers
Phys Med Biol, 66 (6), 065012
DOI 10.1088/1361-6560/abe553, PubMed 33666176

Moe YM, Groendahl AR, Tomic O, Dale E, Malinen E, Futsaether CM (2021)
Deep learning-based auto-delineation of gross tumour volumes and involved nodes in PET/CT images of head and neck cancer patients
Eur J Nucl Med Mol Imaging, 48 (9), 2782-2792
DOI 10.1007/s00259-020-05125-x, PubMed 33559711

Slørdahl KS, Klotz D, Olsen JÅ, Skovlund E, Undseth C, Abildgaard HL, Brændengen M, Nesbakken A, Larsen SG, Hanekamp BA, Holmboe L, Tvedt R, Sveen A, Lothe RA, Malinen E, Kaasa S, Guren MG (2021)
Treatment outcomes and prognostic factors after chemoradiotherapy for anal cancer
Acta Oncol, 60 (7), 921-930
DOI 10.1080/0284186X.2021.1918763, PubMed 33966592

Wright P, Arnesen MR, Lønne PI, Suilamo S, Silvoniemi A, Dale E, Minn H, Malinen E (2021)
Repeatability of hypoxia dose painting by numbers based on EF5-PET in head and neck cancer
Acta Oncol, 60 (11), 1386-1391
DOI 10.1080/0284186X.2021.1944663, PubMed 34184605

Publications 2020

Abravan A, Eide HA, Helland Å, Malinen E (2020)
Radiotherapy-related lymphopenia in patients with advanced non-small cell lung cancer receiving palliative radiotherapy
Clin Transl Radiat Oncol, 22, 15-21
DOI 10.1016/j.ctro.2020.02.005, PubMed 32181373

Al-Haidari G, Skovlund E, Undseth C, Rekstad BL, Larsen SG, Åsli LM, Dueland S, Malinen E, Guren MG (2020)
Re-irradiation for recurrent rectal cancer - a single-center experience
Acta Oncol, 59 (5), 534-540
DOI 10.1080/0284186X.2020.1725111, PubMed 32056476

Dahle TJ, Rusten E, Stokkevåg CH, Silvoniemi A, Mairani A, Fjæra LF, Rørvik E, Henjum H, Wright P, Boer CG, Forsback S, Minn H, Malinen E, Ytre-Hauge KS (2020)
The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors
Phys Med, 76, 166-172
DOI 10.1016/j.ejmp.2020.07.003, PubMed 32683269

Fjeldbo CS, Hompland T, Hillestad T, Aarnes EK, Günther CC, Kristensen GB, Malinen E, Lyng H (2020)
Combining imaging- and gene-based hypoxia biomarkers in cervical cancer improves prediction of chemoradiotherapy failure independent of intratumour heterogeneity
EBioMedicine, 57, 102841
DOI 10.1016/j.ebiom.2020.102841, PubMed 32580139

Samnoy AT, Ytre-Hauge KS, Malinen E, Tran L, Rosenfeld A, Povoli M, Kok A, Summanwar A, Rohrich D (2020)
Microdosimetry with a 3D silicon on insulator (SOI) detector in a low energy proton beamline
Radiat. Phys. Chem., 176, 109078
DOI 10.1016/j.radphyschem.2020.109078

van Houdt PJ, Kallehauge JF, Tanderup K, Nout R, Zaletelj M, Tadic T, van Kesteren ZJ, van den Berg CAT, Georg D, Côté JC, Levesque IR, Swamidas J, Malinen E, Telliskivi S, Brynolfsson P, Mahmood F, van der Heide UA, EMBRACE Collaborative Group (2020)
Phantom-based quality assurance for multicenter quantitative MRI in locally advanced cervical cancer
Radiother Oncol, 153, 114-121
DOI 10.1016/j.radonc.2020.09.013, PubMed 32931890

Publications 2019

Abravan A, Eide HA, Løndalen AM, Helland Å, Malinen E (2019)
Mapping Bone Marrow Response in the Vertebral Column by Positron Emission Tomography Following Radiotherapy and Erlotinib Therapy of Lung Cancer
Mol Imaging Biol, 21 (2), 391-398
DOI 10.1007/s11307-018-1226-7, PubMed 29916117

Alluri SR, Pitman KE, Malinen E, Riss PJ (2019)
Synthesis, radiosynthesis, and positron emission tomography neuroimaging using 5-[18 F]fluoro-L-amino suberate
J Labelled Comp Radiopharm, 63 (1), 6-14
DOI 10.1002/jlcr.3814, PubMed 31697846

Grigalavicius M, Mastrangelopoulou M, Berg K, Arous D, Ménard M, Raabe-Henriksen T, Brondz E, Siem S, Görgen A, Edin NFJ, Malinen E, Theodossiou TA (2019)
Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 10 (1), 3986
DOI 10.1038/s41467-019-12042-7, PubMed 31484929

Moan JM, Amdal CD, Malinen E, Svestad JG, Bogsrud TV, Dale E (2019)
The prognostic role of 18F-fluorodeoxyglucose PET in head and neck cancer depends on HPV status
Radiother Oncol, 140, 54-61
DOI 10.1016/j.radonc.2019.05.019, PubMed 31177043

Pitman KE, Alluri SR, Kristian A, Aarnes EK, Lyng H, Riss PJ, Malinen E (2019)
Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts
Eur J Nucl Med Mol Imaging, 46 (10), 2190-2198
DOI 10.1007/s00259-019-04375-8, PubMed 31264167

Pitman KE, Bakke KM, Kristian A, Malinen E (2019)
Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist
Cancer Imaging, 19 (1), 88
DOI 10.1186/s40644-019-0280-y, PubMed 31856923

Rusten E, Rekstad BL, Undseth C, Klotz D, Hernes E, Guren MG, Malinen E (2019)
Anal cancer chemoradiotherapy outcome prediction using 18F-fluorodeoxyglucose positron emission tomography and clinicopathological factors
Br J Radiol, 92 (1097), 20181006
DOI 10.1259/bjr.20181006, PubMed 30810343

Publications 2018

de Lange C, Solberg R, Holtedahl JE, Tulipan A, Barlinn J, Trigg W, Wickstrøm T, Saugstad OD, Malinen E, Revheim ME (2018)
Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs
Nucl Med Biol, 66, 49-57
DOI 10.1016/j.nucmedbio.2018.08.004, PubMed 30257223

Eide HA, Knudtsen IS, Sandhu V, Løndalen AM, Halvorsen AR, Abravan A, Kure EH, Bogsrud TV, Brustugun OT, Kyte JA, Malinen E, Helland Å (2018)
Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy
Adv Radiat Oncol, 3 (2), 130-138
DOI 10.1016/j.adro.2017.12.007, PubMed 29904737

Skjøtskift T, Evensen ME, Furre T, Moan JM, Amdal CD, Bogsrud TV, Malinen E, Dale E (2018)
Dose painting for re-irradiation of head and neck cancer
Acta Oncol, 57 (12), 1693-1699
DOI 10.1080/0284186X.2018.1512753, PubMed 30280623

Tulipan AJ, Vlatkovic L, Malinen E, Brennhovd B, Hole KH, Lie AK, Ragnum HB, Revheim ME, Seierstad T (2018)
Comparison of time curves from dynamic 18F-fluciclovine positron emission tomography and dynamic contrast-enhanced magnetic resonance imaging for primary prostate carcinomas
Phys Imaging Radiat Oncol, 7, 51-57
DOI 10.1016/j.phro.2018.09.003, PubMed 33458405

Publications 2017

Abravan A, Eide HA, Knudtsen IS, Løndalen AM, Helland Å, Malinen E (2017)
Assessment of pulmonary 18F-FDG-PET uptake and cytokine profiles in non-small cell lung cancer patients treated with radiotherapy and erlotinib
Clin Transl Radiat Oncol, 4, 57-63
DOI 10.1016/j.ctro.2017.04.002, PubMed 29594209

Abravan A, Knudtsen IS, Eide HA, Løndalen AM, Helland Å, van Luijk P, Malinen E (2017)
A new method to assess pulmonary changes using 18F-fluoro-2-deoxyglucose positron emission tomography for lung cancer patients following radiotherapy
Acta Oncol, 56 (11), 1597-1603
DOI 10.1080/0284186X.2017.1349336, PubMed 28849707

Arnesen MR, Hellebust TP, Malinen E (2017)
Impact of dose escalation and adaptive radiotherapy for cervical cancers on tumour shrinkage-a modelling study
Phys Med Biol, 62 (6), N107-N119
DOI 10.1088/1361-6560/aa5de2, PubMed 28151724

Dahle TJ, Rykkelid AM, Stokkevåg CH, Mairani A, Görgen A, Edin NJ, Rørvik E, Fjæra LF, Malinen E, Ytre-Hauge KS (2017)
Monte Carlo simulations of a low energy proton beamline for radiobiological experiments
Acta Oncol, 56 (6), 779-786
DOI 10.1080/0284186X.2017.1289239, PubMed 28464743

Johansen S, Norman MH, Dale E, Amdal CD, Furre T, Malinen E, Evensen JF (2017)
Patterns of local-regional recurrence after conformal and intensity-modulated radiotherapy for head and neck cancer
Radiat Oncol, 12 (1), 87
DOI 10.1186/s13014-017-0829-5, PubMed 28545588

Jåstad EO, Torheim T, Villeneuve KM, Kvaal K, Hole EO, Sagstuen E, Malinen E, Futsaether CM (2017)
In Quest of the Alanine R3 Radical: Multivariate EPR Spectral Analyses of X-Irradiated Alanine in the Solid State
J Phys Chem A, 121 (38), 7139-7147
DOI 10.1021/acs.jpca.7b06447, PubMed 28829916

Kristian A, Holtedahl JE, Torheim T, Futsaether C, Hernes E, Engebraaten O, Mælandsmo GM, Malinen E (2017)
Dynamic 2-Deoxy-2-[18F]Fluoro-D-Glucose Positron Emission Tomography for Chemotherapy Response Monitoring of Breast Cancer Xenografts
Mol Imaging Biol, 19 (2), 271-279
DOI 10.1007/s11307-016-0998-x, PubMed 27541026

Li AN, Andersen E, Lervag C, Julin CH, Lyng H, Hellebust TP, Malinen E (2017)
Dynamic contrast enhanced magnetic resonance imaging for hypoxia mapping and potential for brachytherapy targeting
Phys. Imag. Radiat. Oncol., 2, 1-6
DOI 10.1016/j.phro.2017.03.002

Lyng H, Malinen E (2017)
Hypoxia in cervical cancer: from biology to imaging
Clin Transl Imaging, 5 (4), 373-388
DOI 10.1007/s40336-017-0238-7, PubMed 28804704

Malinen E, Hysing LB, Waldeland E, Muren LP (2017)
Bridging imaging and therapy: the role of medical physics in development of precision cancer care
Acta Oncol, 56 (6), 757-760
DOI 10.1080/0284186X.2017.1316869, PubMed 28464737

Rusten E, Rekstad BL, Undseth C, Al-Haidari G, Hanekamp B, Hernes E, Hellebust TP, Malinen E, Guren MG (2017)
Target volume delineation of anal cancer based on magnetic resonance imaging or positron emission tomography
Radiat Oncol, 12 (1), 147
DOI 10.1186/s13014-017-0883-z, PubMed 28874205

Torheim T, Malinen E, Hole KH, Lund KV, Indahl UG, Lyng H, Kvaal K, Futsaether CM (2017)
Autodelineation of cervical cancers using multiparametric magnetic resonance imaging and machine learning
Acta Oncol, 56 (6), 806-812
DOI 10.1080/0284186X.2017.1285499, PubMed 28464746

Publications 2016

Arnesen MR, Rekstad BL, Stokke C, Bruheim K, Løndalen AM, Hellebust TP, Malinen E (2016)
Short-course PET based simultaneous integrated boost for locally advanced cervical cancer
Radiat Oncol, 11, 39
DOI 10.1186/s13014-016-0612-z, PubMed 26968827

Fjeldbo CS, Julin CH, Lando M, Forsberg MF, Aarnes EK, Alsner J, Kristensen GB, Malinen E, Lyng H (2016)
Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer
Clin Cancer Res, 22 (16), 4067-76
DOI 10.1158/1078-0432.CCR-15-2322, PubMed 27012812

Fjeldbo CS, Aarnes EK, Malinen E, Kristensen GB, Lyng H (2016)
Identification and Validation of Reference Genes for RT-qPCR Studies of Hypoxia in Squamous Cervical Cancer Patients
PLoS One, 11 (5), e0156259
DOI 10.1371/journal.pone.0156259, PubMed 27244197

Knudtsen IS, Svestad JG, Skaug Sande EP, Rekstad BL, Rødal J, van Elmpt W, Öllers M, Hole EO, Malinen E (2016)
Validation of dose painting of lung tumours using alanine/EPR dosimetry
Phys Med Biol, 61 (6), 2243-54
DOI 10.1088/0031-9155/61/6/2243, PubMed 26913997

Torheim T, Groendahl AR, Andersen EK, Lyng H, Malinen E, Kvaal K, Futsaether CM (2016)
Cluster analysis of dynamic contrast enhanced MRI reveals tumor subregions related to locoregional relapse for cervical cancer patients
Acta Oncol, 55 (11), 1294-1298
DOI 10.1080/0284186X.2016.1189091, PubMed 27564398

Publications 2015

Arnesen MR, Knudtsen IS, Rekstad BL, Eilertsen K, Dale E, Bruheim K, Helland Å, Løndalen AM, Hellebust TP, Malinen E (2015)
Dose painting by numbers in a standard treatment planning system using inverted dose prescription maps
Acta Oncol, 54 (9), 1607-13
DOI 10.3109/0284186X.2015.1061690, PubMed 26213311

Malinen E, Søvik Å (2015)
Dose or 'LET' painting--What is optimal in particle therapy of hypoxic tumors?
Acta Oncol, 54 (9), 1614-22
DOI 10.3109/0284186X.2015.1062540, PubMed 26198655

Pitman KE, Rusten E, Kristian A, Malinen E (2015)
Variability of dynamic 18F-FDG-PET data in breast cancer xenografts
Acta Oncol, 54 (9), 1399-407
DOI 10.3109/0284186X.2015.1062140, PubMed 26217987

Publications 2014

Arnesen MR, Bruheim K, Malinen E, Hellebust TP (2014)
Spatial dosimetric sensitivity of contouring uncertainties in gynecological 3D-based brachytherapy
Radiother Oncol, 113 (3), 414-9
DOI 10.1016/j.radonc.2014.11.016, PubMed 25434766

Johansen S, Fosså K, Nesvold IL, Malinen E, Fosså SD (2014)
Arm and shoulder morbidity following surgery and radiotherapy for breast cancer
Acta Oncol, 53 (4), 521-9
DOI 10.3109/0284186X.2014.880512, PubMed 24495044

Knudtsen IS, van Elmpt W, Ollers M, Malinen E (2014)
Impact of PET reconstruction algorithm and threshold on dose painting of non-small cell lung cancer
Radiother Oncol, 113 (2), 210-4
DOI 10.1016/j.radonc.2014.09.012, PubMed 25443496

Kristian A, Riss P, Qu H, Milde M, Schoultz BW, Engebraaten O, Mælandsmo GM, Malinen E (2014)
Positron emission tomography and pharmacokinetics of 2-[18F]-fluoroethyl choline for metabolic studies in breast cancer xenografts
Acta Oncol, 53 (8), 1086-92
DOI 10.3109/0284186X.2014.934398, PubMed 25017377

Torheim T, Malinen E, Kvaal K, Lyng H, Indahl UG, Andersen EK, Futsaether CM (2014)
Classification of dynamic contrast enhanced MR images of cervical cancers using texture analysis and support vector machines
IEEE Trans Med Imaging, 33 (8), 1648-56
DOI 10.1109/TMI.2014.2321024, PubMed 24802069

Publications 2013

Andersen EK, Hole KH, Lund KV, Sundfør K, Kristensen GB, Lyng H, Malinen E (2013)
Pharmacokinetic parameters derived from dynamic contrast enhanced MRI of cervical cancers predict chemoradiotherapy outcome
Radiother Oncol, 107 (1), 117-22
DOI 10.1016/j.radonc.2012.11.007, PubMed 23333024

Hellebust TP, Tanderup K, Lervåg C, Fidarova E, Berger D, Malinen E, Pötter R, Petrič P (2013)
Dosimetric impact of interobserver variability in MRI-based delineation for cervical cancer brachytherapy
Radiother Oncol, 107 (1), 13-9
DOI 10.1016/j.radonc.2012.12.017, PubMed 23462706

Johansen S, Tjessem KH, Fosså K, Bosse G, Danielsen T, Malinen E, Fosså SD (2013)
Dose Distribution in the Heart and Cardiac Chambers Following 4-field Radiation Therapy of Breast Cancer: a Retrospective Study
Breast Cancer (Auckl), 7, 41-9
DOI 10.4137/BCBCR.S11118, PubMed 23589693

Kristian A, Nilsen LB, Røe K, Revheim ME, Engebråten O, Mælandsmo GM, Holm R, Malinen E, Seierstad T (2013)
Dynamic (18) F-FDG PET for Assessment of Tumor Physiology in Two Breast Carcinoma Xenografts
Nucl Med Mol Imaging, 47 (3), 173-80
DOI 10.1007/s13139-013-0211-y, PubMed 24900104

Kristian A, Revheim ME, Qu H, Mælandsmo GM, Engebråten O, Seierstad T, Malinen E (2013)
Dynamic (18)F-FDG-PET for monitoring treatment effect following anti-angiogenic therapy in triple-negative breast cancer xenografts
Acta Oncol, 52 (7), 1566-72
DOI 10.3109/0284186X.2013.813634, PubMed 23984812

Malinen E, Muren LP (2013)
Image guided therapy - do we get the picture?
Acta Oncol, 53 (1), 3-5
DOI 10.3109/0284186X.2013.861924, PubMed 24286539

Revheim ME, Kristian A, Malinen E, Bruland ØS, Berner JM, Holm R, Joensuu H, Seierstad T (2013)
Intermittent and continuous imatinib in a human GIST xenograft model carrying KIT exon 17 resistance mutation D816H
Acta Oncol, 52 (4), 776-82
DOI 10.3109/0284186X.2013.770920, PubMed 23480638

Rusten E, Rødal J, Bruland Ø, Malinen E (2013)
Biologic targets identified from dynamic 18FDG-PET and implications for image-guided therapy
Acta Oncol, 52 (7), 1378-83
DOI 10.3109/0284186X.2013.813071, PubMed 23981046

Rødal J, Rusten E, Søvik Å, Skogmo HK, Malinen E (2013)
Functional imaging to monitor vascular and metabolic response in canine head and neck tumors during fractionated radiotherapy
Acta Oncol, 52 (7), 1293-9
DOI 10.3109/0284186X.2013.812800, PubMed 23879646

Tjessem KH, Johansen S, Malinen E, Reinertsen KV, Danielsen T, Fosså SD, Fosså A (2013)
Long-term cardiac mortality after hypofractionated radiation therapy in breast cancer
Int J Radiat Oncol Biol Phys, 87 (2), 337-43
DOI 10.1016/j.ijrobp.2013.05.038, PubMed 23886416

Publications 2012

de Lange C, Malinen E, Qu H, Johnsrud K, Skretting A, Saugstad OD, Munkeby BH (2012)
Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigs
Eur J Nucl Med Mol Imaging, 39 (5), 792-9
DOI 10.1007/s00259-011-2055-y, PubMed 22297457

Edin NJ, Olsen DR, Sandvik JA, Malinen E, Pettersen EO (2012)
Low dose hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but returns after reoxygenation
Int J Radiat Biol, 88 (4), 311-9
DOI 10.3109/09553002.2012.646046, PubMed 22132723

Halle C, Andersen E, Lando M, Aarnes EK, Hasvold G, Holden M, Syljuåsen RG, Sundfør K, Kristensen GB, Holm R, Malinen E, Lyng H (2012)
Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI
Cancer Res, 72 (20), 5285-95
DOI 10.1158/0008-5472.CAN-12-1085, PubMed 22890239

Rusten E, Rødal J, Revheim ME, Skretting A, Bruland OS, Malinen E (2012)
Quantitative dynamic ¹⁸FDG-PET and tracer kinetic analysis of soft tissue sarcomas
Acta Oncol, 52 (6), 1160-7
DOI 10.3109/0284186X.2012.728713, PubMed 23198721

Waldeland E, Ramberg C, Arnesen MR, Helland A, Brustugun OT, Malinen E (2012)
Dosimetric impact of a frame-based strategy in stereotactic radiotherapy of lung tumors
Acta Oncol, 51 (5), 603-9
DOI 10.3109/0284186X.2012.658115, PubMed 22304490

Publications 2011

Andersen EK, Hole KH, Lund KV, Sundfør K, Kristensen GB, Lyng H, Malinen E (2011)
Dynamic contrast-enhanced MRI of cervical cancers: temporal percentile screening of contrast enhancement identifies parameters for prediction of chemoradioresistance
Int J Radiat Oncol Biol Phys, 82 (3), e485-92
DOI 10.1016/j.ijrobp.2011.05.050, PubMed 22014954

Andersen EK, Kristensen GB, Lyng H, Malinen E (2011)
Pharmacokinetic analysis and k-means clustering of DCEMR images for radiotherapy outcome prediction of advanced cervical cancers
Acta Oncol, 50 (6), 859-65
DOI 10.3109/0284186X.2011.578586, PubMed 21767185

Knudtsen IS, Rødal J, Brustugun OT, Helland Å, Skretting A, Malinen E (2011)
Dynamic respiratory gated (18)FDG-PET of lung tumors - a feasibility study
Acta Oncol, 50 (6), 889-96
DOI 10.3109/0284186X.2011.583266, PubMed 21767189

Malinen E, Rødal J, Knudtsen IS, Søvik Å, Skogmo HK (2011)
Spatiotemporal analysis of tumor uptake patterns in dynamic (18)FDG-PET and dynamic contrast enhanced CT
Acta Oncol, 50 (6), 873-82
DOI 10.3109/0284186X.2011.579161, PubMed 21767187

Rødal J, Waldeland E, Søvik A, Malinen E (2011)
Dosimetric verification of biologically adapted IMRT
Med Phys, 38 (5), 2586-94
DOI 10.1118/1.3581406, PubMed 21776795

Waldeland E, Helt-Hansen J, Malinen E (2011)
Characterization of lithium formate EPR dosimeters for high dose applications - Comparison with alanine
Radiat. Meas., 46 (2), 213-218
DOI 10.1016/j.radmeas.2010.11.015

Waldeland E, Malinen E (2011)
Review of the dose-to-water energy dependence of alanine and lithium formate EPR dosimeters and LiF TL-dosimeters - Comparison with Monte Carlo simulations
Radiat. Meas., 46 (9), 945-951
DOI 10.1016/j.radmeas.2011.03.014

Publications 2010

Rødal J, Søvik A, Malinen E (2010)
Influence of MLC leaf width on biologically adapted IMRT plans
Acta Oncol, 49 (7), 1116-23
DOI 10.3109/0284186X.2010.498832, PubMed 20831503

Rødal J, Søvik S, Skogmo HK, Knudtsen IS, Malinen E (2010)
Feasibility of contrast-enhanced cone-beam CT for target localization and treatment monitoring
Radiother Oncol, 97 (3), 521-4
DOI 10.1016/j.radonc.2010.07.006, PubMed 20667609

Røe K, Aleksandersen TB, Kristian A, Nilsen LB, Seierstad T, Qu H, Ree AH, Olsen DR, Malinen E (2010)
Preclinical dynamic 18F-FDG PET - tumor characterization and radiotherapy response assessment by kinetic compartment analysis
Acta Oncol, 49 (7), 914-21
DOI 10.3109/0284186X.2010.498831, PubMed 20831478

Søvik A, Malinen E, Olsen DR (2010)
Adapting biological feedback in radiotherapy
Semin Radiat Oncol, 20 (2), 138-46
DOI 10.1016/j.semradonc.2009.11.008, PubMed 20219552

Søvik A, Rødal J, Skogmo HK, Lervåg C, Eilertsen K, Malinen E (2010)
Adaptive radiotherapy based on contrast enhanced cone beam CT imaging
Acta Oncol, 49 (7), 972-7
DOI 10.3109/0284186X.2010.498433, PubMed 20831484

Waldeland E, Hole EO, Sagstuen E, Malinen E (2010)
The energy dependence of lithium formate and alanine EPR dosimeters for medium energy x rays
Med Phys, 37 (7), 3569-75
DOI 10.1118/1.3432567, PubMed 20831064

Waldeland E, Hole EO, Stenerlöw B, Grusell E, Sagstuen E, Malinen E (2010)
Radical formation in lithium formate EPR dosimeters after irradiation with protons and nitrogen ions
Radiat Res, 174 (2), 251-7
DOI 10.1667/RR2035.1, PubMed 20681791

Waldeland E, Hörling M, Hole EO, Sagstuen E, Malinen E (2010)
Dosimetry of stereotactic radiosurgery using lithium formate EPR dosimeters
Phys Med Biol, 55 (8), 2307-16
DOI 10.1088/0031-9155/55/8/012, PubMed 20354284

Wright P, Muren LP, Høyer M, Malinen E (2010)
Evaluation of adaptive radiotherapy of bladder cancer by image-based tumour control probability modelling
Acta Oncol, 49 (7), 1045-51
DOI 10.3109/0284186X.2010.498431, PubMed 20831494

Publications 2009

Seierstad T, Hole KH, Saelen E, Ree AH, Flatmark K, Malinen E (2009)
MR-guided simultaneous integrated boost in preoperative radiotherapy of locally advanced rectal cancer following neoadjuvant chemotherapy
Radiother Oncol, 93 (2), 279-84
DOI 10.1016/j.radonc.2009.08.046, PubMed 19800704

Søvik A, Malinen E, Olsen DR (2009)
Strategies for biologic image-guided dose escalation: a review
Int J Radiat Oncol Biol Phys, 73 (3), 650-8
DOI 10.1016/j.ijrobp.2008.11.001, PubMed 19215819

Søvik S, Skogmo HK, Andersen EK, Bruland ØS, Olsen DR, Malinen E (2009)
DCEMRI of spontaneous canine tumors during fractionated radiotherapy: a pharmacokinetic analysis
Radiother Oncol, 93 (3), 618-24
DOI 10.1016/j.radonc.2009.08.012, PubMed 19747746

Publications 2008

Gancheva V, Yordanov ND, Callens F, Vanhaelewyn G, Raffi J, Bortolin E, Onori S, Malinen E, Sagstuen E, Fabislak S, Peimel-Stuglik Z (2008)
An international intercomparison on "self-calibrated" alanine EPR dosimeters
Radiat. Phys. Chem., 77 (3), 357-364
DOI 10.1016/j.radphyschem.2007.06.004

Røe K, Muren LP, Rørvik J, Olsen DR, Dahl O, Bakke A, Malinen E (2008)
Dynamic contrast enhanced magnetic resonance imaging of bladder cancer and implications for biological image-adapted radiotherapy
Acta Oncol, 47 (7), 1257-64
DOI 10.1080/02841860802244174, PubMed 18618299

Røthe Arnesen M, Eilertsen K, Malinen E (2008)
Optimal treatment margins for radiotherapy of prostate cancer based on interfraction imaging
Acta Oncol, 47 (7), 1373-81
DOI 10.1080/02841860802244190, PubMed 18654907

Sastre-Padro M, Lervåg C, Eilertsen K, Malinen E (2008)
The performance of multileaf collimators evaluated by the stripe test
Med Dosim, 34 (3), 202-6
DOI 10.1016/j.meddos.2008.08.005, PubMed 19647629

Søvik A, Kippenes Skogmo H, Bruland ØS, Rune Olsen D, Malinen E (2008)
DCEMRI monitoring of canine tumors during fractionated radiotherapy
Acta Oncol, 47 (7), 1249-56
DOI 10.1080/02841860802244166, PubMed 18618342

Publications 2007

Malinen E, Waldeland E, Hole EO, Sagstuen E (2007)
The energy dependence of lithium formate EPR dosimeters for clinical electron beams
Phys Med Biol, 52 (14), 4361-9
DOI 10.1088/0031-9155/52/14/022, PubMed 17664613

Sastre-Padro M, Welleweerd J, Malinen E, Eilertsen K, Olsen DR, van der Heide UA (2007)
Consequences of leaf calibration errors on IMRT delivery
Phys Med Biol, 52 (4), 1147-56
DOI 10.1088/0031-9155/52/4/019, PubMed 17264376

Søvik A, Malinen E, Skogmo HK, Bentzen SM, Bruland OS, Olsen DR (2007)
Radiotherapy adapted to spatial and temporal variability in tumor hypoxia
Int J Radiat Oncol Biol Phys, 68 (5), 1496-504
DOI 10.1016/j.ijrobp.2007.04.027, PubMed 17674980

Søvik A, Ovrum J, Olsen DR, Malinen E (2007)
On the parameter describing the generalised equivalent uniform dose (gEUD) for tumours
Phys Med, 23 (3-4), 100-6
DOI 10.1016/j.ejmp.2007.09.001, PubMed 17962057

Publications 2006

Johansen S, Olsen DR, Danielsen T, Malinen E (2006)
Contralateral breast doses following radiotherapy of the breast and regional lymph nodes: Measurements and treatment planning calculations
Radiother Oncol, 82 (3), 332-6
DOI 10.1016/j.radonc.2006.08.018, PubMed 16962677

Malinen E, Søvik A, Hristov D, Bruland ØS, Olsen DR (2006)
Adapting radiotherapy to hypoxic tumours
Phys Med Biol, 51 (19), 4903-21
DOI 10.1088/0031-9155/51/19/012, PubMed 16985278

Malinen E, Waldeland E, Hole EO, Sagstuen E (2006)
LET effects following neutron irradiation of lithium formate EPR dosimeters
Spectrochim Acta A Mol Biomol Spectrosc, 63 (4), 861-9
DOI 10.1016/j.saa.2005.10.017, PubMed 16495132

Osterås BH, Hole EO, Olsen DR, Malinen E (2006)
EPR dosimetry of radiotherapy photon beams in inhomogeneous media using alanine films
Phys Med Biol, 51 (24), 6315-28
DOI 10.1088/0031-9155/51/24/003, PubMed 17148820

Søvik A, Malinen E, Bruland ØS, Bentzen SM, Olsen DR (2006)
Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study
Phys Med Biol, 52 (2), 499-513
DOI 10.1088/0031-9155/52/2/013, PubMed 17202629

Publications 2005

Lund E, Gustafsson H, Danilczuk M, Sastry MD, Lund A, Vestad TA, Malinen E, Hole EO, Sagstuen E (2005)
Formates and dithionates: sensitive EPR-dosimeter materials for radiation therapy
Appl Radiat Isot, 62 (2), 317-24
DOI 10.1016/j.apradiso.2004.08.015, PubMed 15607468

Publications 2004

Malinen E, Vestad TA, Hult EA, Hole EO, Sagstuen E (2004)
Estimation of X-ray beam quality by electron paramagnetic resonance (EPR) spectroscopy
Appl Radiat Isot, 60 (6), 929-37
DOI 10.1016/j.apradiso.2004.02.005, PubMed 15110359

Vestad TA, Malinen E, Olsen DR, Hole EO, Sagstuen E (2004)
Electron paramagnetic resonance (EPR) dosimetry using lithium formate in radiotherapy: comparison with thermoluminescence (TL) dosimetry using lithium fluoride rods
Phys Med Biol, 49 (20), 4701-15
DOI 10.1088/0031-9155/49/20/003, PubMed 15566169

Publications 2003

Malinen E (2003)
Simulation studies and quantitative analysis using electron paramagnetic resonance spectroscopy: radiation-induced radicals in alanine and pyrimidine bases
In Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo, The Faculty, Oslo, no. 285, 1 b. (flere pag.)
BIBSYS 031181112

Malinen E, Heydari MZ, Sagstuen E, Hole EO (2003)
Alanine radicals, part 3: properties of the components contributing to the EPR spectrum of X-irradiated alanine dosimeters
Radiat Res, 159 (1), 23-32
DOI 10.1667/0033-7587(2003)159[0023:arppot]2.0.co;2, PubMed 12492365

Malinen E, Hult EA, Hole EO, Sagstuen E (2003)
Alanine radicals, part 4: relative amounts of radical species in alanine dosimeters after exposure to 6-19 MeV electrons and 10 kV-15 MV photons
Radiat Res, 159 (2), 149-53
DOI 10.1667/0033-7587(2003)159[0149:arprao]2.0.co;2, PubMed 12537519

Malinen E, Sagstuen E (2003)
Radical formation in pyrimidine bases after X, proton and alpha-particle irradiation
Radiat Res, 160 (2), 186-97
DOI 10.1667/3085, PubMed 12859229

Sankovic K, Malinen E, Medunic Z, Sagstuen E, Herak JN (2003)
Hole transfer in crystals of cytosine monohydrate: an EPR study
Phys. Chem. Chem. Phys., 5 (8), 1665-1670
DOI 10.1039/b211108j

Vestad TA, Malinen E, Lund A, Hole EO, Sagstuen E (2003)
EPR dosimetric properties of formates
Appl Radiat Isot, 59 (2-3), 181-8
DOI 10.1016/s0969-8043(03)00165-9, PubMed 12941509

Publications 2002

Heydari MZ, Malinen E, Hole EO, Sagstuen E (2002)
Alanine radicals. 2. The composite polycrystalline alanine EPR spectrum studied by ENDOR, thermal annealing, and spectrum simulations
J. Phys. Chem. A, 106 (38), 8971-8977
DOI 10.1021/jp026023c

Publications 2001

Kummermehr J, Malinen E, Freykowski S, Sund M, Trott KR (2001)
The influence of autologous tumor fibroblasts on the radiosensitivity of squamous cell carcinoma megacolonies
Int J Radiat Oncol Biol Phys, 50 (1), 229-37
DOI 10.1016/s0360-3016(01)01454-7, PubMed 11316568

Publications 2000

Malinen E, Freykowski S, Kummermehr J (2000)
Regrowth delay analysis of irradiated tumors in the curative dose region
Int J Radiat Oncol Biol Phys, 46 (1), 173-7
DOI 10.1016/s0360-3016(99)00423-x, PubMed 10656390

Publications 1995

Malinen E (1995)
Stråleskader i tymin og cytosin ved røntgen-, proton- og _a-bestråling: et ESR-studium av LET-effekter
[E. Malinen], Oslo, 115 s.
BIBSYS 951535293

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